*{box-sizing:border-box}body{margin:0}:root{--bg:#f5f6f8;--panel:#fff;--border:#d7dbe0;--text:#1f2933;--muted:#6b7280;--accent:#2563eb;--gene-neutral:140,140,140;--current-gene:34,197,94;--other-gene:147,51,234}body{background:var(--bg);color:var(--text);margin:0;font-family:-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,sans-serif}header{background:var(--panel);border-bottom:1px solid var(--border);flex-wrap:wrap;align-items:center;gap:14px;padding:12px 20px;display:flex}.app-logo{flex:none;width:162px;height:auto;max-height:36px;display:block}select,input[type=text]{border:1px solid var(--border);background:#fff;border-radius:6px;padding:7px 9px;font-size:13px}label.file-label{color:var(--muted);border:1px dashed var(--border);cursor:pointer;border-radius:6px;align-items:center;gap:6px;padding:6px 10px;font-size:12px;display:flex;position:relative;overflow:hidden}label.file-label:hover{border-color:var(--accent);color:var(--accent)}label.file-label.onboarding-highlight{overflow:visible}label.file-label input{display:none}label.file-label .fname{text-overflow:ellipsis;white-space:nowrap;max-width:220px;overflow:hidden}label.file-label .file-label-text{z-index:1;text-overflow:ellipsis;white-space:nowrap;max-width:260px;position:relative;overflow:hidden}label.file-label .progress-fill{background:#2563eb2e;width:0%;transition:width .15s linear;position:absolute;inset:0}label.file-label-progress{cursor:default}.tsl-label{color:var(--muted);white-space:nowrap;align-items:center;gap:6px;font-size:12px;display:flex}.tsl-label select{padding:5px 7px;font-size:12px}.layout-toggle{border:1px solid var(--border);border-radius:6px;display:flex;overflow:hidden}.layout-btn{border:none;border-right:1px solid var(--border);color:var(--muted);cursor:pointer;background:#fff;padding:6px 10px;font-size:12px}.layout-btn:last-child{border-right:none}.layout-btn:hover{color:var(--accent)}.layout-btn.active{background:var(--accent);color:#fff}#geneAddressBarWrap{max-width:420px;margin-top:8px;position:relative}#geneAddressBar{box-sizing:border-box;width:100%}#geneAddressBar:disabled{color:var(--muted);background:#f0f1f3}#suggestions{background:var(--panel);border:1px solid var(--border);z-index:10;border-radius:6px;max-height:320px;position:absolute;top:38px;left:0;right:0;overflow-y:auto;box-shadow:0 4px 10px #00000014}#suggestions .row{cursor:pointer;border-bottom:1px solid #eee;justify-content:space-between;gap:10px;padding:8px 10px;font-size:13px;display:flex}#suggestions .row.active{background:#f0f4ff}.sugg-meta{color:var(--muted);white-space:nowrap;font-size:12px}#status{color:var(--muted);text-align:right;min-width:220px;font-size:12px}#legend{background:var(--panel);border-bottom:1px solid var(--border);color:var(--muted);flex-wrap:wrap;gap:18px;padding:7px 20px;font-size:12px;display:flex}#legend .legend-row{flex-wrap:wrap;align-items:center;gap:18px;display:flex}#legend .group{align-items:center;gap:12px;display:flex}#legend .sep{background:var(--border);width:1px;height:14px}#legend .item{align-items:center;gap:5px;display:flex}.box{vertical-align:middle;border-radius:2px;width:12px;height:10px;display:inline-block}.box.style-unique{background:rgb(var(--current-gene))}.box.style-partial{background:repeating-linear-gradient(45deg, rgba(var(--current-gene),.9), rgba(var(--current-gene),.9) 2px, rgba(var(--current-gene),.22) 2px, rgba(var(--current-gene),.22) 4px);border:1px solid rgba(var(--current-gene),.9)}.box.style-gene{border:1.5px solid rgb(var(--current-gene));background:0 0}.box.style-multi{background:rgba(var(--gene-neutral),.25);border:1px dotted rgba(var(--gene-neutral),.85)}.box.colour-current-gene{background:rgb(var(--current-gene))}.box.colour-other-gene{background:rgb(var(--other-gene))}.box.colour-no-gene{background:rgba(var(--gene-neutral),.25);border:1px dotted rgba(var(--gene-neutral),.85)}#geneTabs{margin:16px 20px 0}.tab-strip{flex-wrap:wrap;align-items:flex-start;gap:8px;display:flex}.gene-tab{border:1px solid var(--border);background:var(--panel);cursor:pointer;border-bottom:none;border-radius:8px 8px 0 0;flex-direction:column;gap:2px;min-width:160px;max-width:260px;padding:8px 26px 8px 12px;display:flex;position:relative}.gene-tab:hover{border-color:var(--accent)}.gene-tab.active{border-color:var(--accent);background:#eaf1ff}.gene-tab-label{color:var(--text);text-overflow:ellipsis;white-space:nowrap;font-size:13px;font-weight:600;overflow:hidden}.gene-tab-coords{color:var(--muted);white-space:nowrap;font-size:11px}.gene-tab-close{width:18px;height:18px;color:var(--muted);cursor:pointer;background:0 0;border:none;border-radius:4px;font-size:14px;line-height:16px;position:absolute;top:4px;right:4px}.gene-tab-close:hover{color:var(--text);background:#00000014}.gene-tab-add{border:1px dashed var(--border);min-width:44px;color:var(--muted);cursor:pointer;background:0 0;border-bottom:none;border-radius:8px 8px 0 0;justify-content:center;align-items:center;font-size:18px;display:flex}.gene-tab-add:hover{border-color:var(--accent);color:var(--accent)}.gene-tab-add-empty{min-width:220px;min-height:46px;font-size:32px}.onboarding-highlight{z-index:20;animation:1.6s ease-in-out infinite onboardingPulse;position:relative;box-shadow:0 0 0 3px #2563eb2e;border-color:var(--accent)!important}.onboarding-highlight:after{content:attr(data-onboarding-hint);color:#fff;white-space:normal;text-align:left;pointer-events:none;background:#1f2933;border-radius:6px;width:max-content;max-width:280px;padding:8px 10px;font-size:12px;font-weight:500;line-height:1.35;position:absolute;top:calc(100% + 10px);left:0;box-shadow:0 6px 18px #0000002e}.onboarding-highlight:before{content:"";pointer-events:none;border:6px solid #0000;border-bottom-color:#1f2933;position:absolute;top:calc(100% + 4px);left:18px}.onboarding-highlight-right:after{top:50%;left:calc(100% + 12px);transform:translateY(-50%)}.onboarding-highlight-right:before{border:6px solid #0000;border-right-color:#1f2933;top:50%;left:calc(100% + 1px);transform:translateY(-50%)}@keyframes onboardingPulse{0%,to{box-shadow:0 0 0 3px #2563eb29}50%{box-shadow:0 0 0 6px #2563eb42}}#statsRow{flex-wrap:wrap;align-items:center;gap:14px;margin:10px 20px 0;display:flex}#statsPanel{background:var(--panel);border:1px solid var(--border);border-radius:8px;min-width:0;padding:10px 14px;font-size:13px}.stats-row{flex-wrap:wrap;align-items:center;gap:18px;display:flex}.stats-nr{align-items:center;gap:5px;display:flex}.stats-loading{color:var(--muted)}#viewButton{background:var(--accent);color:#fff;cursor:pointer;border:none;border-radius:6px;flex-shrink:0;padding:7px 14px;font-size:13px}#viewButton:hover:not(:disabled){background:#1d4ed8}#viewButton:disabled{color:#f0f1f3;cursor:not-allowed;background:#b9c0cc}#plot-container{background:var(--panel);box-sizing:border-box;height:100%;min-height:60px;padding:10px;overflow:auto}#panelArea{height:calc(100vh - 220px);min-height:420px;margin:0 20px 16px}.panel-grid{gap:10px;height:100%;display:grid}.panel-grid.layout-1{grid-template-rows:1fr;grid-template-columns:1fr}.panel-grid.layout-2{grid-template-rows:1fr;grid-template-columns:1fr 1fr}.panel-grid.layout-4{grid-template-rows:1fr 1fr;grid-template-columns:1fr 1fr}.alignment-panel{border:1px solid var(--border);background:var(--panel);border-radius:8px;flex-direction:column;height:100%;min-height:0;display:flex;overflow:hidden}.alignment-panel-header{border-bottom:1px solid var(--border);background:#eef1f5;flex-shrink:0;align-items:center;gap:8px;padding:6px 10px;font-size:12px;display:flex}.panel-source-select{min-width:0;color:var(--text);flex:1;padding:4px 6px;font-size:12px;font-weight:600}.lock-toggle{border:1px solid var(--border);cursor:pointer;color:var(--muted);background:#fff;border-radius:6px;flex-shrink:0;padding:3px 8px;font-size:11px}.lock-toggle.locked{color:var(--accent);border-color:var(--accent);background:#eaf1ff}.lock-toggle:hover{border-color:var(--accent)}.alignment-panel-body{flex:1;min-height:0;overflow:auto}.alignment-panel-body #plot-container{border:none;border-radius:0;margin:0}.panel-message{text-align:center;color:var(--muted);padding:24px;font-size:13px}.panel-message-error{color:#b91c1c}#placeholder{background:var(--panel);border:1px solid var(--border);box-sizing:border-box;border-radius:8px;place-items:center;min-height:420px;margin:0 20px 16px;padding:48px 24px;display:grid}.welcome-content{text-align:center;width:min(100%,660px)}.welcome-logo{width:min(320px,75vw);height:auto;margin:0 auto 26px;display:block}.welcome-intro{color:var(--muted);text-align:left;margin:0 auto 30px;font-size:14px;line-height:1.65}.welcome-intro a{color:var(--accent)}.welcome-intro a:hover{text-decoration-thickness:2px}.welcome-intro a:focus-visible{outline:2px solid var(--accent);outline-offset:2px;border-radius:2px}.welcome-privacy{color:var(--text);text-align:left;margin:0 auto 30px;font-size:14px;font-weight:600;line-height:1.55}.welcome-content h1{letter-spacing:0;margin:0 0 20px;font-size:20px;font-weight:650;line-height:1.25}.welcome-steps{color:var(--text);text-align:left;margin:0 auto;padding-left:28px;font-size:15px;line-height:1.5}.welcome-steps li{margin-bottom:14px;padding-left:8px}.welcome-steps li:last-child{margin-bottom:0}.welcome-steps li::marker{color:var(--accent);font-weight:700}.app-footer{color:var(--muted);text-align:center;padding:8px 20px 12px;font-size:12px}.app-footer a{color:inherit}.app-footer a:hover{color:var(--accent)}.app-footer a:focus-visible{outline:2px solid var(--accent);outline-offset:2px;border-radius:2px}@media (width<=600px){#placeholder{min-height:360px;padding:36px 20px}.welcome-logo{margin-bottom:24px}}.plot-toolbar{flex-wrap:wrap;align-items:center;gap:8px;margin-bottom:8px;display:flex}.transcript-sort-select{border:1px solid var(--border);background:#fff;border-radius:6px;padding:4px 6px;font-size:12px}.minimum-read-filter{color:var(--muted);align-items:center;gap:5px;font-size:11px;display:flex}.minimum-read-filter input{border:1px solid var(--border);border-radius:6px;width:64px;padding:3px 5px;font-size:12px}.plot-hint{color:var(--muted);margin-left:auto;font-size:11px}.plot-footer-spacer{height:160px}canvas{display:block}canvas:focus-visible{outline:2px solid var(--accent);outline-offset:-2px}#tooltip{pointer-events:auto;-webkit-user-select:text;user-select:text;color:#fff;z-index:50;cursor:text;background:#1f2933;border-radius:6px;max-width:320px;padding:6px 28px 6px 9px;font-size:12px;line-height:1.5;position:fixed;box-shadow:0 4px 10px #0003}.tooltip-close{color:#ffffffbf;cursor:pointer;-webkit-user-select:none;user-select:none;background:0 0;border:none;border-radius:4px;width:18px;height:18px;font-size:15px;line-height:18px;position:absolute;top:4px;right:5px}.tooltip-close:hover{color:#fff;background:#ffffff24}.cigar-wrap{flex-wrap:wrap;row-gap:2px;font-family:ui-monospace,Menlo,Consolas,monospace;font-size:11px;display:flex}